Efficient Maximum Likelihood Estimation for Pedigree Data with the Sum-Product Algorithm
نویسندگان
چکیده
منابع مشابه
Efficient Maximum Likelihood Estimation for Pedigree Data with the Sum-Product Algorithm.
OBJECTIVE We analyze data sets consisting of pedigrees with age at onset of colorectal cancer (CRC) as phenotype. The occurrence of familial clusters of CRC suggests the existence of a latent, inheritable risk factor. We aimed to compute the probability of a family possessing this risk factor as well as the hazard rate increase for these risk factor carriers. Due to the inheritability of this r...
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ژورنال
عنوان ژورنال: Human Heredity
سال: 2016
ISSN: 0001-5652,1423-0062
DOI: 10.1159/000475465